A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer

A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer

We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We con...

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Veröffentlicht in:Case reports in endocrinology 2020-03, Vol.2020 (2020), p.1-4
Hauptverfasser: Shakil, Jawairia, Osuna, Patricia Mejia, Thomas, Jessica S., Robbins, Richard J.
Format: Artikel
Sprache:eng
Schlagworte:
Case Report
Case reports
Gene mutations
Genetic aspects
Genetic research
Kinases
Lymphatic system
Mutation
Patients
Thyroid cancer
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Zusammenfassung:We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.
ISSN:2090-6501
2090-651X
DOI:10.1155/2020/7641940