Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study

Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether historically inferior outcome data still hold true. From a total of 475 eligible MM patients w...

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Veröffentlicht in:	BMC cancer 2018-10, Vol.18 (1), p.1008-1008, Article 1008
Hauptverfasser:	Antlanger, Marlies, Dust, Tobias, Reiter, Thomas, Böhm, Alexandra, Lamm, Wolfgang W, Gornicec, Max, Willenbacher, Ella, Nachbaur, David, Weger, Roman, Rabitsch, Werner, Rasoul-Rockenschaub, Susanne, Worel, Nina, Lechner, Daniel, Greinix, Hildegard, Keil, Felix, Gisslinger, Heinz, Agis, Hermine, Krauth, Maria-Theresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Autografts Autologous stem cell transplantation Bone marrow Care and treatment Chemotherapy Chronic illnesses Cohort analysis Cohort Studies Complications and side effects Diagnosis Epidermal growth factor receptors Female Frailty Glomerular filtration rate Glomerular Filtration Rate - physiology Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - mortality Hematopoietic Stem Cell Transplantation - trends Hemodialysis Humans Immunoglobulins Kidney diseases Kidney failure Male Middle Aged Mortality Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - mortality Multiple Myeloma - therapy Overall survival Patient outcomes Physiological aspects Progression-free survival Renal failure Renal function Renal impairment Renal Insufficiency - diagnosis Renal Insufficiency - mortality Renal Insufficiency - therapy Retrospective Studies Stem cell transplantation Stem cells Transplantation, Autologous - methods Transplantation, Autologous - mortality Transplantation, Autologous - trends Transplants & implants Treatment Outcome
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Zusammenfassung:	Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether historically inferior outcome data still hold true. From a total of 475 eligible MM patients who had undergone ASCT between 1998 and 2016, 374 were included in this multi-centric retrospective cohort study. Renal function was determined both at the time of MM diagnosis and ASCT by estimated glomerular filtration rate (eGFR according to the MDRD formula, RI defined as eGFR
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-018-4926-0