Targeted therapy for multiple gene mutations in multiple metastases of advanced gastric cancer: a case report

In China, gastric cancer is the second most common cause of cancer-related death, after lung cancer. At present, the morbidity and mortality rates of gastric cancer are increasing, and targeted therapy for gastric cancer has become a research hotspot. Herein, we report a patient with multiple metastases from advanced gastric cancer. After identifying gene amplification, initial treatment induced regression of the tumor. However, in later stages, due to the overexpression or mutation of , , , and other genes, the targeted drug therapy became ineffective, and the disease progressed rapidly, leading to the death of the patient.