The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses

The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses

Background: It is plausible that maternal pregnancy metabolism influences the risk of offspring congenital heart disease (CHD). We sought to explore this through a systematic approach using different methods and data. Methods: We undertook multivariable logistic regression of the odds of CHD for 923...

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Veröffentlicht in:Journal of cardiovascular development and disease 2022-07, Vol.9 (8), p.237
Hauptverfasser: Taylor, Kurt, McBride, Nancy, Zhao, Jian, Oddie, Sam, Azad, Rafaq, Wright, John, Andreassen, Ole A, Stewart, Isobel D, Langenberg, Claudia, Magnus, Maria Christine, Borges, Maria Carolina, Caputo, Massimo, Lawlor, Deborah A
Format: Artikel
Sprache:eng
Schlagworte:
ALSPAC
Biomarkers
Born in Bradford
Cohort analysis
congenital heart disease
Datasets
Genomes
Mass spectrometry
Medical research
Metabolites
MoBa
Multiple births
NMR
Nuclear magnetic resonance
Outdoor air quality
Pregnancy
Scientific imaging
Womens health
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Zusammenfassung:Background: It is plausible that maternal pregnancy metabolism influences the risk of offspring congenital heart disease (CHD). We sought to explore this through a systematic approach using different methods and data. Methods: We undertook multivariable logistic regression of the odds of CHD for 923 mass spectrometry (MS)-derived metabolites in a sub-sample of a UK birth cohort (Born in Bradford (BiB); N = 2605, 46 CHD cases). We considered metabolites reaching a p-value threshold
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd9080237