gem‐Diethyl Pyrroline Nitroxide Spin Labels: Synthesis, EPR Characterization, Rotamer Libraries and Biocompatibility

Invited for this month's cover picture is the group of Professor Enrica Bordignon at the Ruhr University Bochum. The cover picture shows an artistic view of E. coli cells and two spin‐labeled recombinantly produced proteins, which can be inserted into the cells for EPR studies. The primary sequence of the proteins is schematically shown with the one‐letter amino acid code, and cysteine residues are functionalized with the two new gem diethyl nitroxide spin labels designed to better sustain the reducing cellular environment. Read the full text of their Full Paper at 10.1002/open.201900119. “This study is part of the efforts of the Cluster of Excellence RESOLV, in which several research groups investigate the role of the solvent in the mediation, control and regulation of chemical reactions. In this article, the focus is on the strategies adopted by proteins to change their structure inside a cell …” Find out more about the story behind the front cover research at 10.1002/open.201900119.