Multicentricity and its associated clinicopathological risk factors in renal cell carcinoma

Aims : Although nephron-sparing tumor surgery (NSS) has become a routine procedure for renal tumors under certain precautions in many centers, due to the incidence of multifocality, it still remains controversial. This study examines some clinical and pathological risk factors associated with multifocal renal tumors and also factors contributing to the success or failure of NSS. Materials and Methods: From 2000-2005, 130 patients with renal cell carcinoma (RCC) who had undergone radical nephrectomy were included in this study at one academic center. The clinicopathologic features of these cases were reviewed and categorized to identify risk factors of multifocality including age, gender, size and side of the tumor, presence of vascular invasion, Fuhrman's grade, and clinical and pathological stages. Statistical Analysis: Data were expressed as mean. Statistical significance among groups was evaluated using Chi-square test and Fisher's exact test when appropriate. Student's t test was used for comparison of two means. Multiple logistic regression analysis was performed for risk factors of multicentricity. P