Association of early menarche with breast tumor molecular features and recurrence

Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tumor-adjacent normal tissues (N = 666) from women in the Nurses' Health St...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research : BCR 2024-06, Vol.26 (1), p.102-14
Hauptverfasser:	Harris, Alexandra R, Wang, Tengteng, Heng, Yujing J, Baker, Gabrielle M, Le, Phuong Anh, Wang, Jun, Ambrosone, Christine, Brufsky, Adam, Couch, Fergus J, Modugno, Francesmary, Scott, Christopher G, Vachon, Celine M, Hankinson, Susan E, Rosner, Bernard A, Tamimi, Rulla M, Peng, Cheng, Eliassen, A Heather
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult Age Age at menarche Age Factors AKT protein Analysis Biomarkers, Tumor - genetics Breast cancer Breast cancer recurrence Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer therapies Care and treatment Cell adhesion Cell cycle Chemotherapy Early menarche gene expression signature Early-life risk factors of breast tumor biology Endocrine therapy ErbB-2 protein Exercise Extracellular matrix Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene set enrichment analysis Genetic aspects Health aspects Humans Inflammation Medical diagnosis Medical prognosis Medical records Menarche Menarche - genetics Middle Aged Myc protein Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Oxidative phosphorylation Oxidative stress Phosphorylation Prognosis Protein folding Quality control Questionnaires Relapse Reproductive risk factors of breast cancer Risk Factors TOR protein Transcriptome Transcriptomes Tumors Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tumor-adjacent normal tissues (N = 666) from women in the Nurses' Health Studies (NHS) to investigate whether early menarche (age
ISSN:	1465-5411 1465-542X 1465-542X
DOI:	10.1186/s13058-024-01839-0