P13.03 The Patients with Lacunar Ischemic Stroke (Lis) Have Endothelial Dysfunction (Ed) and Increased Arterial Stiffness

ED is thought to be implicated in the pathogenesis of cerebral small vessel disease in patients with LIS while the role of arterial stiffness is less known. Objective The aim of this study was to assess the endothelial function (EF) and arterial stiffness in patients with LIS. Methods In this study, 35 patients with LIS, as defined by clinical characteristics and MRI findings were compared with 18 healthy age and gender-matched patients with similar risk factors. EF was assessed using the brachial flow-mediated vasodilatation (FMD); in LIS group on the first day after stroke onset. Carotid stiffness index ß was calculated as follows: ln(systolic/diastolic blood pressure)/([Dmax-Dmin]/ Dmin), where Dmax and Dmin are maximum and minimum common carotid lumen diameters measured by carotid ultrasound. Carotid intima-media thickness (IMT) was also measured. FMD was categorized according to ROC analysis and ED was defined as FMD ≤ 6.0%. Results Twenty-two (63%) LIS patients had ED on the 1st day and only three patients (17%) in the control group (p