The landscape of small cell lung cancer metastases: Organ specificity and timing

The landscape of small cell lung cancer metastases: Organ specificity and timing

Background Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood‐borne metastases in a comprehensive large cohort of SCLC patients. M...

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Veröffentlicht in:Thoracic cancer 2021-03, Vol.12 (6), p.914-923
Hauptverfasser: Megyesfalvi, Zsolt, Tallosy, Bernadett, Pipek, Orsolya, Fillinger, Janos, Lang, Christian, Klikovits, Thomas, Schwendenwein, Anna, Hoda, Mir Alireza, Renyi‐Vamos, Ferenc, Laszlo, Viktoria, Rezeli, Melinda, Moldvay, Judit, Dome, Balazs
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal glands
Bones
Brain research
Cancer and Oncology
Cancer och onkologi
Cancer therapies
Clinical Medicine
Ethics
Gender
Klinisk medicin
Liver
Localization
Lung cancer
Medical and Health Sciences
Medical prognosis
Medical records
Medicin och hälsovetenskap
Metastasis
metastasis pattern
Original
Response rates
small cell lung cancer
survival
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Zusammenfassung:Background Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood‐borne metastases in a comprehensive large cohort of SCLC patients. Methods In this retrospective non‐interventional cross‐sectional study of 1009 Caucasian SCLC patients, we investigated the correlation between the distinct locations of the primary tumor and metastatic sites. Results The onset of bone (p 
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.13854