Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A

Esophageal squamous cell carcinoma (ESCC), a malignant neoplasm with high incidence, is a severe global public health threat. The current modalities used for treating ESCC include surgery, chemotherapy, and radiotherapy. Although ESCC management and treatment strategies have improved over the last d...

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Veröffentlicht in:	Cell death & disease 2022-02, Vol.13 (2), p.189-189, Article 189
Hauptverfasser:	Bao, Zhuo, Li, Ang, Lu, Xuebo, Wang, Zitong, Yu, Yin, Wu, Wenjie, Zhao, Lili, Li, Bo, Wu, Xiangyu, Laster, Kyle Vaughn, Zhang, Chengjuan, Jiang, Yanan, Dong, Zigang, Liu, Kangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/89 631/80/83 64/60 692/699/67/2195 82/51 82/58 Animal models Animals Antacids Antibodies Aurora kinase Aurora Kinase A - antagonists & inhibitors Aurora Kinase A - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Chemotherapy Dyspepsia Esophageal cancer Esophageal Neoplasms - drug therapy Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - genetics Esophagitis Esophagus Ethanolamines - therapeutic use Gene Expression Regulation, Neoplastic Humans Immunology Life Sciences Metastases Metastasis Mice Neoplasia Neoplasm Metastasis Patients Public health Radiation therapy Squamous cell carcinoma Tumors Xenografts
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Zusammenfassung:	Esophageal squamous cell carcinoma (ESCC), a malignant neoplasm with high incidence, is a severe global public health threat. The current modalities used for treating ESCC include surgery, chemotherapy, and radiotherapy. Although ESCC management and treatment strategies have improved over the last decade, the overall 5-year survival rate remains
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-022-04642-x