Clostridium butyricum Prevents Dysbiosis and the Rise in Blood Pressure in Spontaneously Hypertensive Rats

Hypertension is accompanied by dysbiosis and a decrease in the relative abundance of short-chain fatty acid (SCFA)-producing bacteria. However, there is no report to examine the role of in blood pressure regulation. We hypothesized that a decrease in the relative abundance of SCFA-producing bacteria in the gut was the cause of spontaneously hypertensive rats (SHR)-induced hypertension. and captopril were used to treat adult SHR for six weeks. modulated SHR-induced dysbiosis and significantly reduced systolic blood pressure (SBP) in SHR ( < 0.01). A 16S rRNA analysis determined changes in the relative abundance of the mainly SCFA-producing bacteria , , and , which increased significantly. Total SCFAs, and particularly butyrate concentrations, in the SHR cecum and plasma were reduced ( < 0.05), while prevented this effect. Likewise, we supplemented SHR with butyrate for six weeks. We analyzed the flora composition, cecum SCFA concentration, and inflammatory response. The results showed that butyrate prevented SHR-induced hypertension and inflammation, and the decline of cecum SCFA concentrations ( < 0.05). This research revealed that increasing cecum butyrate concentrations by probiotics, or direct butyrate supplementation, prevented the adverse effects of SHR on intestinal flora, vascular, and blood pressure.