P2.51 Preclinical Atherosclerotic Disease and Metabolic Syndrome: A Prediabetes Stage?

Aim In ESH/ESC 07 Guidelines, Metabolic Syndrome (MS) and subclinical vascular disease (VD) are stressed as important markers of high risk in asymptomatic subjects. We compared the severity of VD by ultrasonography in patients (p.) with MS and Diabetes Mellitus (DM) and control (C) p. to analyze the relationship between the metabolic condition and the severity of VD. Methods We did in the same procedure 1) CIMT 2) Plaques characterization, 3) PWV and 4) FMD with a strict quality control. We set a score (VS) from 0 to 5 according to the severity of the VD. The CV Risk using Framingham score (FS) was also obtained from medical records. Results We performed a cross sectional, observational study on 292 matched p., 125 C without dyslipemia or overweight, 138 with MS (according ATP III criteria) and 29 with DM.. Parameter C (n= 125) MS (n= 138) DBT (n= 29) p Age 54 ± 12 54 ± 11 51 ± 10 NS Sex (% males) 70 64 52 NS SBP (mmHg) 141 ± 18 141 ± 16 142 ± 10 NS DBP (mmHg) 85 ± 11 86 ± 9 87 ±10 NS HR (bpm) 69 ± 9 71 ± 10 74 ± 10 NS % abnormal IMT 19 33 41 .012 % Plaques 22 54 55 < 001 %Abnormal FMD 33 39 45 NS %Abnormal PWV 30 38 65 .002 FS (mean) 10 ± 8 10 ± 6 25 ± 12 < 001 VS (mean) 2,1 ± 1,4 2,5 ±1,4 3,0 ± 1,7 .004 Conclusions 1- In a selected population of matched p. according to age, sex and BP, there seems to be an increase in the degree of VD when MS is present. 2- The pattern of VD in MS p. was close to that in DM p. consistent with the described increase in CV risk in MS.3-A VS may be useful in the clinical practice.