Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes

Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes

An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-08, Vol.27 (16), p.5195
Hauptverfasser: Philippova, Anna N, Vorobyeva, Daria V, Gribanov, Pavel S, Godovikov, Ivan A, Osipov, Sergey N
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Amines
Amino acids
Analysis
azepines
Biosynthesis
Cancer
Carboxylates
Catalysis
Chemical properties
Chromatography
cyclic amino acids
cyclization
Kinases
Mass spectrometry
Ring formation (Chemistry)
Scientific imaging
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27165195