Cholera Toxin as a Probe for Membrane Biology

Cholera Toxin as a Probe for Membrane Biology

Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its...

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Veröffentlicht in:Toxins 2021-08, Vol.13 (8), p.543
Hauptverfasser: Kenworthy, Anne K, Schmieder, Stefanie S, Raghunathan, Krishnan, Tiwari, Ajit, Wang, Ting, Kelly, Christopher V, Lencer, Wayne I
Format: Artikel
Sprache:eng
Schlagworte:
Binding sites
Biology
Biophysics
Cell Membrane - metabolism
Cholera
Cholera toxin
Cholera Toxin - metabolism
Cholera toxin B subunit
Clathrin - metabolism
Endocytosis
Glycosphingolipids
Hypotheses
Lipids
membrane curvature
membrane nanodomains
membrane rafts
Membrane structure
Membrane structures
Membranes
Pathogens
Plasma
Proteins
Receptors, Cell Surface - metabolism
retrograde trafficking
Review
Toxins
Waterborne diseases
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Beschreibung
Zusammenfassung:Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its dynamics including vesicular trafficking and nanodomain assembly. Here, we review important advances in these fields enabled by use of CTxB and its lipid receptor GM1.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins13080543