Analyses of circRNA profiling during the development from pre-receptive to receptive phases in the goat endometrium
Recent studies have revealed that noncoding RNAs play important regulatory roles in the formation of endometrial receptivity. Circular RNAs (circRNAs) are a universally expressed noncoding RNA species that have been recently proposed to act as miRNA sponges that directly regulate expression of targe...
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Veröffentlicht in: | Journal of Animal Science and Biotechnology 2019-04, Vol.10 (1), p.34-16, Article 34 |
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Sprache: | eng |
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Zusammenfassung: | Recent studies have revealed that noncoding RNAs play important regulatory roles in the formation of endometrial receptivity. Circular RNAs (circRNAs) are a universally expressed noncoding RNA species that have been recently proposed to act as miRNA sponges that directly regulate expression of target genes or parental genes.
We used Illumina Solexa technology to analyze the expression profiles of circRNAs in the endometrium from three goats at gestational day 5 (pre-receptive endometrium, PE) and three goats at gestational day 15 (receptive endometrium, RE). Overall, 21,813 circRNAs were identified, of which 5,925 circRNAs were specific to the RE and 9,078 were specific to the PE, which suggested high stage-specificity. Further analysis found 334 differentially expressed circRNAs in the RE compared with PE ( |
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ISSN: | 1674-9782 2049-1891 2049-1891 |
DOI: | 10.1186/s40104-019-0339-4 |