Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort

Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort

Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationship to the ubiquitin-proteasome system and the effects of insulin on ubiquitinated proteins...

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Veröffentlicht in:Arthritis research & therapy 2024-09, Vol.26 (1), p.171-10, Article 171
Hauptverfasser: Ruscitti, Piero, Currado, Damiano, Rivellese, Felice, Vomero, Marta, Navarini, Luca, Cipriani, Paola, Pitzalis, Costantino, Giacomelli, Roberto
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - metabolism
Blotting, Western
Cells, Cultured
Cohort Studies
Complications and side effects
Development and progression
Diabetes Mellitus, Type 2 - metabolism
Female
Gene expression
Genetic aspects
Health aspects
Humans
IL-1β, ubiquitin
Immunohistochemistry
Insulin - metabolism
Interleukin-1
Interleukin-1 - genetics
Interleukin-1 - metabolism
Male
Middle Aged
Of Early Arthritis Cohort study (PEAC)
Pathobiology
Proteasome Endopeptidase Complex - genetics
Proteasome Endopeptidase Complex - metabolism
Rheumatoid arthritis
Signal Transduction - physiology
Synovial biopsy
Synovial Membrane - metabolism
Synoviocytes - drug effects
Synoviocytes - metabolism
Type 2 diabetes
Ubiquitin - metabolism
Ubiquitin-proteasome system
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Zusammenfassung:Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationship to the ubiquitin-proteasome system and the effects of insulin on ubiquitinated proteins in fibroblast-like synoviocytes (FLSs). The synovial expression of IL-1 pathway genes was compared in early (
ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-024-03392-9