Human induced pluripotent stem cell line HMUi001-A derived from corneal stromal cells

Human induced pluripotent stem cell line HMUi001-A derived from corneal stromal cells

A human corneal stroma induced pluripotent stem cell (HMUi001-A) line was created from primary cultured human corneal fibroblasts. Reprogramming was performed using episomal vector delivery of OCT4, SOX2, KLF4, L-MYC and LIN28. Further characterization of the HMUi001-A confirmed that the cell line w...

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Veröffentlicht in:Stem cell research 2019-05, Vol.37, p.101409-101409, Article 101409
Hauptverfasser: Bikkuzin, Timur, Shi, Yan, Sun, Baoqi, Guo, Yiyuan, Jin, Xin, Han, Zhenbo, Pavlov, Valentin, Zhang, Hong
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Corneal Stroma - cytology
Fibroblasts - cytology
Humans
Induced Pluripotent Stem Cells - cytology
Male
Young Adult
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Zusammenfassung:A human corneal stroma induced pluripotent stem cell (HMUi001-A) line was created from primary cultured human corneal fibroblasts. Reprogramming was performed using episomal vector delivery of OCT4, SOX2, KLF4, L-MYC and LIN28. Further characterization of the HMUi001-A confirmed that the cell line was pluripotent, free from Epstein Barr viral genome, and retained normal karyotype.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2019.101409