Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

SARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary...

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Veröffentlicht in:BIO web of conferences 2021-01, Vol.30, p.5008
Hauptverfasser: Iatsenko, Viktoria, Boyarshin, Konstantin, Bespalova, Olga, Klyueva, Violetta, Kurkina, Yuliya, Batlutskaya, Irina
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Sprache:eng
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Zusammenfassung:SARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary structures demonstrate very low homology and different calculating parameters. This time they both are affected by stabilizing selection and in natural viral populations do not tend to be deleted. The question whether in this case very different proteins could share the same function rises from the present data.
ISSN:2117-4458
2273-1709
2117-4458
DOI:10.1051/bioconf/20213005008