EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer’s disease mouse model by suppressing β-amyloid generation

[Display omitted] •EPA-pPE exerted better effects than EPA-PE and Egg-PE in suppressing Aβ generation.•EPA-pPE obviously improved cognition of high-fat feeding SAMP8 mice.•EPA-pPE suppressed oxidative stress, hyper-phosphorylated tau, neuro-inflammation and apoptosis.•EPA-pPE might be applied as functional ingredients to relieve neurodegenerative disease. EPA enriched ethanolamine plasmalogens (EPA-pPE) are important bioactive components and widely distributed in multifarious marine products. In the present study, Chinese hamster ovary cells stably transfected with APP751 and PS1 (CHO-APP/PS1 cells) and high-fat feeding SAMP8 mice were used to study the effects of EPA-pPE on Alzheimer’s disease (AD). The in vitro experiments showed that EPA-pPE exerted better effects than EPA-PE and Egg-PE in decreasing the intracellular and extracellular Aβ levels. EPA-pPE obviously improved learning and memory function of high-fat feeding SAMP8 mice by Morris maze test. Further mechanism research indicated that EPA-pPE could significantly improve cognition of Alzheimer’s disease by suppressing β-amyloid generation via reducing levels of APP and altering APP cleavage, thereby inhibiting oxidative stress, hyper-phosphorylated tau, neuro-inflammation and apoptosis. These results suggested that EPA-pPE might be applied as food supplements and/or functional ingredients to relieve neurodegenerative disease.