Association between omentin and obstructive sleep apnea: A meta‐analysis

Background Obstructive sleep apnea (OSA) can lead to multisystem and multiorgan damage, which has attracted widespread attention from scholars. The pathogenesis of OSA is complex, and obesity plays an important role. Adipokine is secreted by adipose tissue, and its abnormal expression may be closely related to OSA. The relationship between omentin (a novel adipokine) and OSA is controversial. This study focuses on the important role of omentin in OSA and explores whether it can be regarded as a new target for the diagnosis and treatment of OSA. Method PubMed, Embase, Web of Science, the Cochrane library, WANFANG, VIP, and Chinese National Knowledge Infrastructure were systematically searched for retrieving eligible studies until May 2022. Documents were screened according to strict inclusion and exclusion criteria, and data were extracted using Excel spreadsheets. The quality of the literature was assessed using the Newcastle–Ottawa Scale. RevMan 5.3 and Stata 12.0 software were used in this meta‐analysis for data synthesis. Result A total of eight eligible studies with 23 databases involving 914 participants were included in this meta‐analysis. Combined data indicated that omentin levels in OSA patients were lower than that in controls (standardized mean difference = −1.54, 95% confidence interval = −2.07 to −1.00, p