Early expression of urinary neutrophil gelatinase-associated lipocalin biomarker predicts acute kidney injury complicating circulatory shock

The novel urinary neutrophil gelatinase-associated lipocalin (uNGAL) is an early and highly predictive biomarker that is rapidly released in acute kidney injury (AKI). We investigated the early expression of uNGAL (first 4 days after injury) as a predictor of acute kidney injury complicating circulatory shock. Urinary-NGAL level was measured in collected urine samples of 45 patients (pts) with circulatory shock, during the first 6 h and after 24 h of onset of shock. Eleven patients responded to fluid infusion ± vasopressors and were considered as a control group. The estimated uNGAL at day 1 and day 2, could predict AKI presenting at days 2, 3 and 4 (P