The osteogenic differentiation stimulating activity of Sea cucumber methanolic crude extraction on rat bone marrow mesenchymal stem cells

Sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. This study was performed to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rBMMSc) into osteogenic lineage. Isolated rBMMSc were grown in DMEM supplement...

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Veröffentlicht in:	Iranian journal of basic medical sciences 2014-08, Vol.17 (8), p.626-631
Hauptverfasser:	Baharara, Javad, Amini, Elaheh, Kerachian, Mohammad Amin, Soltani, Mozhgan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Differentiation Marine Osteogenic Short Communication
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Zusammenfassung:	Sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. This study was performed to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rBMMSc) into osteogenic lineage. Isolated rBMMSc were grown in DMEM supplemented with 10% FBS. The cells were exposed to different concentration of extract. After 21 days, Alizarin red staining, alkaline phosphatase assay and RT-PCR were performed. The results were analyzed by ANOVA software and P value
ISSN:	2008-3866 2008-3874