P7.4 Morning Central Blood Pressure Surge Does Not Differ Between Men and Women

Objective To assess if 24h urinary cortisol metabolite (UCM) profiles are related to structural cardiac and arterial parameters in those with or at risk of Type 2 diabetes mellitus (T2DM). Design and method 32 participants, 25–77 years, eGFR> 45 mL/min and no serious illness. Urine was collected over 24 hours. 2D echocardiography and arterial stiffness measures [aortic pulse wave velocity (aPWV) by Arteriograph and cardio-ankle vascular index (CAVI) by VaSera] were performed on the collection day. Steroids were extracted from urine and hydrolysed; derivatives were analysed by GC-MS. Results Seven UCMs were quantified [tetrahydrocortisol (THF), allo -tetrahydrocortisol ( a -THF), tetrahydrocortisone (THE), α-cortol (α-col), β-cortol (β-col), α-cortolone (α-cone), β-cortolone (β-cone)]. Left ventricular mass index (LVMI) correlated positively with 24h cortisol:-cortisone metabolites (THF+ a THF+αcol+βcol/THE+αcortolone+βcortolone) and negatively with α:β metabolites (αcol+αcortol/βcol+βcortol), when indexed for body surface area (BSA) and height (r = 0.37, 0.48 and r = −0.34, −0.49 respectively). Further, there was a positive relationship between LVMI BSA and THF:THE (r = 0.35). aPWV but not CAVI was also related to 24h cortisol:cortisone metabolites (r = 0.45). All p