Bidirectional Comparisons Revealed Functional Patterns in Interaction between Salmonella enterica and Plants

Plants may harbor the human pathogen . Interactions between . and different plant species have been studied in individual reports. However, disparities arising from the distinct experimental conditions may render a meaningful comparison very difficult. This study explored interaction patterns between different . strains including serovars Typhimurium 14028s and LT2 and serovar Senftenberg, and different plants (Arabidopsis, lettuce, and tomato) in one approach. Better persistence of . serovar Typhimurium strains was observed in all tested plants, whereas the resulting symptoms varied depending on plant species. Genes encoding pathogenesis-related proteins were upregulated in plants inoculated with . Furthermore, transcriptome of tomato indicated dynamic responses to , with strong and specific responses already 24 h after inoculation. By comparing with publicly accessible Arabidopsis and lettuce transcriptome results generated in a similar manner, constants and variables were displayed. Plants responded to with metabolic and physiological adjustments, albeit with variability in reprogrammed orthologues. At the same time, adapted to plant leaf-mimicking media with changes in biosynthesis of cellular components and adjusted metabolism. This study provides insights into the -plant interaction, allowing for a direct comparison of responses and adaptations in both organisms.