Conjugate vaccines and the carriage of Haemophilus influenzae type b

Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the bacterium. The remarkable success of current vaccination programs against Hib has been due in part to the effect of co...

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Veröffentlicht in:	Emerging infectious diseases 1996-07, Vol.2 (3), p.176-182
1. Verfasser:	Barbour, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier State - immunology England Haemophilus Infections - prevention & control Haemophilus Infections - transmission Haemophilus influenzae Haemophilus Vaccines - immunology Haemophilus Vaccines - therapeutic use Humans United Kingdom
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Zusammenfassung:	Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the bacterium. The remarkable success of current vaccination programs against Hib has been due in part to the effect of conjugate Hib vaccines in decreasing carriage of Hib. This review explores evidence for this effect, and discusses the possible mechanisms of the mucosal influence of Hib conjugate vaccines.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid0203.960303