A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals

[Display omitted] •Unique genome-wide association study of multiple EDCs in 24-hour urine.•Four independent SNPs associated with EDCs through multi-trait GWAS analysis.•SNPs in CYP450 and SLC genes associated with MECPP and MEHHP.•CYP2C9 and SLC17A1 likely play causal roles in phthalate metabolism and excretion. Ubiquitous exposure to environmental endocrine disrupting chemicals (EDCs) instigates a major public health problem, but much remains unknown on the inter-individual differences in metabolism and excretion of EDCs. To examine this we performed a two-stage genome-wide association study (GWAS) for 24-hour urinary excretions of four parabens, two bisphenols, and nine phthalate metabolites. Results showed five genome-wide significant (p-value