Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population

We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide...

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Veröffentlicht in:	Brazilian journal of medical and biological research 2017-01, Vol.50 (11), p.e6613-e6613
Hauptverfasser:	Gu, Q-L, Han, Y, Lan, Y-M, Li, Y, Kou, W, Zhou, Y-S, Hai, X-J, Yan, B, Ci, C-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis Apolipoprotein B gene Apolipoproteins Apolipoproteins B - genetics Asian Continental Ancestry Group - genetics BIOLOGY Blood lipids Case-Control Studies China - ethnology Female Gene Frequency Genetic aspects Genetic Association Studies Haplotypes Health aspects Humans Hyperlipidemia Hyperlipidemias - ethnology Hyperlipidemias - genetics Linear Models Lipids - blood Male MEDICINE, RESEARCH & EXPERIMENTAL Middle Aged Polymorphism, Single Nucleotide Public health Risk Assessment Risk Factors Serum lipids Single nucleotide polymorphism Single nucleotide polymorphisms Yugur minority
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Zusammenfassung:	We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P
ISSN:	0100-879X 1414-431X 1414-431X
DOI:	10.1590/1414-431x20176613