Trypanosoma cruzi : a stage-specific calpain-like protein is induced after various kinds of stress

Calpains are calcium-dependent cysteine proteinases found in all living organisms and are involved in diverse cellular processes. Calpain-like proteins have been reported after in silico analysis of the Tritryps genome and are believed to play important roles in cell functions of trypanosomatids. We...

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Veröffentlicht in:	Memórias do Instituto Oswaldo Cruz 2008-09, Vol.103 (6), p.598-601
Hauptverfasser:	Giese, Viviane, Dallagiovanna, Bruno, Marchini, Fabricio K, Pavoni, Daniela P, Krieger, Marco A, Goldenberg, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calpain - biosynthesis Calpain - genetics calpain-like calpain-like - Trypanosoma cruzi - stress - metacyclogenesis Life Cycle Stages - genetics Life Cycle Stages - physiology metacyclogenesis Polymerase Chain Reaction Protozoan Proteins - biosynthesis Protozoan Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism stress Trypanosoma cruzi Trypanosoma cruzi - genetics Trypanosoma cruzi - growth & development
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Zusammenfassung:	Calpains are calcium-dependent cysteine proteinases found in all living organisms and are involved in diverse cellular processes. Calpain-like proteins have been reported after in silico analysis of the Tritryps genome and are believed to play important roles in cell functions of trypanosomatids. We describe the characterization of a member of this family, which is differentially expressed during the life-cycle of Trypanosoma cruzi .
ISSN:	1678-8060 0074-0276 1678-8060 0074-0276
DOI:	10.1590/S0074-02762008000600015