Elevated circulating follistatin associates with an increased risk of type 2 diabetes

The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin le...

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Veröffentlicht in:	Nature communications 2021-11, Vol.12 (1), p.6486-6486, Article 6486
Hauptverfasser:	Wu, Chuanyan, Borné, Yan, Gao, Rui, López Rodriguez, Maykel, Roell, William C., Wilson, Jonathan M., Regmi, Ajit, Luan, Cheng, Aly, Dina Mansour, Peter, Andreas, Machann, Jürgen, Staiger, Harald, Fritsche, Andreas, Birkenfeld, Andreas L., Tao, Rongya, Wagner, Robert, Canouil, Mickaël, Hong, Mun-Gwan, Schwenk, Jochen M., Ahlqvist, Emma, Kaikkonen, Minna U., Nilsson, Peter, Shore, Angela C., Khan, Faisel, Natali, Andrea, Melander, Olle, Orho-Melander, Marju, Nilsson, Jan, Häring, Hans-Ulrich, Renström, Erik, Wollheim, Claes B., Engström, Gunnar, Weng, Jianping, Pearson, Ewan R., Franks, Paul W., White, Morris F., Duffin, Kevin L., Vaag, Allan Arthur, Laakso, Markku, Stefan, Norbert, Groop, Leif, De Marinis, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 14 14/19 38/43 38/44 45/43 631/208/205/2138 692/163/2743/137/773 Adaptor Proteins, Signal Transducing - blood Adipocytes Adipose tissue Adipose Tissue - metabolism Body fat Clinical Medicine Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Endocrinology and Diabetes Endokrinologi och diabetes Fatty acids Fatty liver Follistatin Follistatin - blood Genome-wide association studies Genome-Wide Association Study Genomes Glucokinase Health risks Hepatocytes Hepatocytes - metabolism Humanities and Social Sciences Humans Hyperglycemia Insulin Insulin resistance Insulin Resistance - physiology Klinisk medicin Lipolysis Liver diseases Medical and Health Sciences Medicin och hälsovetenskap Middle Aged multidisciplinary Non-alcoholic Fatty Liver Disease - blood Pathogenesis Risk Science Science (multidisciplinary) Secretion
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Zusammenfassung:	The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04–1.47, p
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-26536-w