Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis

•Pancytopenia is a possible side effect of interferon-gamma (IFN-γ) treatment.•Pancytopenia may limit adjuvant IFN-γ treatment for disseminated nocardiosis.•First clinical report of pancytopenia following IFN-γ treatment.•Basic research supports the causative role of IFN-γ treatment for pancytopenia. A patient with disseminated nocardiosis developed pancytopenia after treatment with recombinant interferon-gamma (IFN-γ). While no previous clinical reports link pancytopenia to IFN-γ, our observations align with basic research on myelosuppressive effects of IFN-γ. Adjunctive IFN-γ may improve standard nocardiosis therapy, but vigilant monitoring of its hematologic effects is necessary.