Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy

Pulmonary emphysema (PE) has been demonstrated to have a high prevalence in patients with locally advanced non-small cell lung cancer (NSCLC). A total of 153 patients with locally advanced NSCLC were enrolled in this study to investigate the association between PE and radiation pneumonitis (RP) afte...

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Veröffentlicht in:Scientific reports 2017-06, Vol.7 (1), p.2748-9, Article 2748
Hauptverfasser: Zhou, Ziyang, Song, Xiao, Wu, Ailu, Liu, Hui, Wu, Hongyu, Wu, Qiongya, Liu, Yu, Li, Yefei, Cai, Yong, Liang, Shixiong
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Sprache:eng
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Zusammenfassung:Pulmonary emphysema (PE) has been demonstrated to have a high prevalence in patients with locally advanced non-small cell lung cancer (NSCLC). A total of 153 patients with locally advanced NSCLC were enrolled in this study to investigate the association between PE and radiation pneumonitis (RP) after definitive thoracic radiation therapy (TRT). The incidence of RP in Grade 2, 3 and 5 were 11.1%, 9.8% and 0.7%, respectively. Univariate analysis revealed that age, PE, forced vital capacity (FVC), arterial partial pressure of oxygen (PO 2 ) and mean lung dose (MLD) were significantly associated with the risk of Grade ≥2 or Grade ≥3 RP in patients with squamous cell carcinoma (SCC, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-02739-4