Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets

Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray containing 11 267 individual prostatectomy specim...

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Veröffentlicht in:	Molecular oncology 2021-07, Vol.15 (7), p.1956-1969
Hauptverfasser:	Spethmann, Tanja, Böckelmann, Lukas Clemens, Labitzky, Vera, Ahlers, Ann‐Kristin, Schröder‐Schwarz, Jennifer, Bonk, Sarah, Simon, Ronald, Sauter, Guido, Huland, Hartwig, Kypta, Robert, Schumacher, Udo, Lange, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Androgen receptors Androgens Antibodies Antigens Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Breast cancer Cancer patients Care and treatment Catenin cell adhesion Cell proliferation CHD1 Datasets ERG Forkhead Transcription Factors Foxp1 protein gamma Catenin Gene expression Genomes Humans junction plakoglobin Lymph nodes Male Medical prognosis Metastases Metastasis Oncogene Proteins, Fusion - metabolism Patients Phosphatase Prognosis Prostate cancer Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - surgery Proteins PTEN protein Repressor Proteins Surgery Tissue Array Analysis Tumor suppressor genes Tumorigenesis Tumors WNT signaling
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Zusammenfassung:	Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray containing 11 267 individual prostatectomy specimens. Considering all patients, high JUP expression was associated with adverse tumor stage (P = 0.0002), high Gleason grade (P
ISSN:	1574-7891 1878-0261
DOI:	10.1002/1878-0261.12922