Febrile seizures: is there a significance of chronological ranking of fever and seizure?

Introduction:Seizures observed in febrile disease periods in healthy children aged from 3 months to 6 years are known as febrile seizures (FS). There is usually a chronological sequence involving seizure following fever in most FS, but some cases may not follow this pattern. This study investigated the chronological relation between fever and convulsion and whether clinical and laboratory findings affect this. Methods:Patients with FS between 1 December, 2015, and 1 April, 2016, were included in this study. Cases with a regular fever plus seizure chronological sequence were classified as classical FS. Without a regular chronological sequence, fever after seizure, were classified as non-classical FS. The effect on both groups of parameters such as gender, age, height, weight, type of FS (simple or complex), previous history of FS, family history of FS, family history of epilepsy, qualitative c-reactive protein (CRP) and white blood cell (WBC) count were evaluated. Results:Twenty-seven percent of FS were non-classical and 73% were classical. Negative CRP and low WBC emerged as significant predictors of non-classical FS at binary logistic regression (OR=1.388, 95% CI 1.051-1.834 and OR=9.021, 95% CI 1.298-62.702, respectively). Other factors such as gender, age, height, weight, type of FS, previous history of FS, familyhistory of FS, familyhistory of epilepsyhad no effect in terms of nonclassic FS. Conclusions:Acute inflammatory response findings such as increased CRP, WBC and fever may not accompany in non-classical FS. Although the diagnosis of FS is correct in such cases, misunderstandings may occur between the physician and parents because of the nomenclature employed. Giriş: 3 ay-6 yaş arası sağlıklı çocuklarda ateşli hastalık dönemlerinde görülen nöbetlere febril nöbetler (FN)denilmektedir. FN’lerin çoğunda ateş sonrası nöbet zamansal sıralaması görülmekte iken bazı vakalarda bu durum görülmemektedir. Bu çalışmada FN’li hastalarda ateş ve nöbetin zamansal sıralaması ve klinik ve laboratuar bulguların bu zamansal sıralamaya etkilerinin olup olmadığı araştırılmıştır. Yöntem: 1 Aralık 2015 ve 1 Nisan 2016 tarihleri arasında FN tanısı alan hastalar çalışmaya alındı. Ateş sonrası nöbet zamansal sıralaması gösteren vakalar klasik FN olarak sınıflandırıldı. Ateş sonrası nöbet zamansal sıralaması göstermeyen vakalar ise klasik olmayan FN olarak sınıflandırıldı. Cinsiyet, yaş, boy, vücut ağırlığı, febril nöbet tipi (basit, kompleks), daha önce geçirilmiş FN hika