Determinação condutométrica de captopril em formulações farmacêuticas utilizando sulfato de cobre(II) como titulante Conductometric determination of captopril in pharmaceutical formulations using copper(II) sulphate as titrant

A simple and rapid conductometric method for captopril determination using copper(II) sulphate solution as titrant was developed. The method was based on the chemical reaction between captopril and Cu(II) ions yielding a precipitate. The conductance of the solution was monitored as a function of the added volume of titrant. The method was applied with success for captopril determination in three pharmaceutical formulations. The relative standard deviation for six successive measurements was smaller than 0.5%. Recovery values from three samples, ranging from 97.7 to 103%, were obtained.