Single-cell RNA sequencing identifies the properties of myelodysplastic syndrome stem cells

HSCs architectures in MDS can also predict therapeutic reaction [1]. [...]the high-resolution analysis of HSCs is of great significance. LSCs may have similar mechanisms to survive and resist to chemotherapy. [...]abnormal ribosome biogenesis is an important feature during development and progression of MDS and may be also related to therapeutic resistance. Abbreviations DEG: differentially expressed gene HD: healthy donor HSC: hematopoietic stem cell HR-MDS: higher-risk myelodysplastic syndrome LSC: leukemia stem cell Lin− : Lineage negative LR-MDS: lower-risk myelodysplastic syndrome MPP: multipotent progenitor MDS: myelodysplastic syndrome sAML: secondary acute myeloid leukemia scRNA-seq: single-cell RNA sequencing TCGA: