Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-03, Vol.25 (6), p.1389
Hauptverfasser:	Svenningsen, Søren Wedel, Frederiksen, Rikki Franklin, Counil, Claire, Ficker, Mario, Leisner, Jørgen J, Christensen, Jørn Bolstad
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents antimicrobial compounds Bacteria Ciprofloxacin Ciprofloxacin - chemistry Ciprofloxacin - pharmacology Conjugates dendrimers Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology E coli Glycoproteins Gram-negative bacteria Gram-Negative Bacteria - growth & development Gram-Positive Bacteria - growth & development Peptides Salmonella
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Beschreibung
Zusammenfassung:	Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25061389