Associations of autozygosity with a broad range of human phenotypes

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confoundi...

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Veröffentlicht in:	NATURE COMMUNICATIONS 2019-10, Vol.10 (1), p.4957-17, Article 4957
Hauptverfasser:	Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Lin, Kuang, Deelen, Patrick, Schurmann, Claudia, Baumbach, Clemens, Fuchsberger, Christian, Gao, He, Jia, Yucheng, van der Most, Peter J, Priyanka, Tallapragada Divya Sri, Salvi, Erika, Smart, Melissa C, Spracklen, Cassandra N, Verweij, Niek, Warren, Helen R, Yousri, Noha A, Zhao, Wei, Borja, Judith B, Bottinger, Erwin P, Broer, Linda, Concas, Maria Pina, Damulina, Anna, Daneshpour, Maryam S, Delgado, Graciela E, Freedman, Barry I, Goel, Anuj, Goodarzi, Mark O, Graff, Mariaelisa, Grodstein, Francine, Guo, Yu, Halevy, Avner, Höfer, Imo, Huang, Jinyan, Kanai, Masahiro, Kessler, Thorsten, Khor, Chiea Chuen, Kutalik, Zoltán, Launer, Lenore J, Lerch, Markus M, London, Stephanie J, Loomis, Stephanie, Luan, Jian’an, Manichaikul, Ani W, Meitinger, Thomas, Milani, Lili, Millwood, Iona Y, Ong, Ken K, Orozco, Lorena, Pattaro, Cristian, Pattie, Alison, Räikkönen, Katri, Ralhan, Sarju, van Rooij, Frank J A, Sabanayagam, Charumathi, van Setten, Jessica, Sever, Peter J, Shi, Yuan, Shrestha, Smeeta, Starr, John M, Tham, Yih-Chung, Tillander, Annika, Yuan, Jian-Min, Zhang, Liang, Bennett, David A, van den Berg, Leonard H, Berndt, Sonja I, Bielak, Lawrence F, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Caulfield, Mark J, Cesarini, David, Eriksson, Johan G, Feitosa, Mary, Gieger, Christian, Goyette, Philippe, Gyllensten, Ulf, Hakonarson, Hakon, Hunt, Steven C, Jaddoe, Vincent W V, Karpe, Fredrik, März, Winfried, McCarthy, Mark I, Metspalu, Andres, Oldehinkel, Albertine J, Palmas, Walter, Pasterkamp, Gerard G, Porteous, David J, Rotimi, Charles, Sanghera, Dharambir K, Toniolo, Daniela, Wang, Carol A, Magnusson, Patrik K. E., Uitterlinden, André G, Franceschini, Nora, Hayward, Caroline, Walters, Robin G, Perry, John R. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/1397 631/208/205 631/208/721 631/208/730 Alleles Basic Medicine Blood pressure Body Size Body Size - genetics Breeding success Children Cognition Consanguinity Estimates Fertility Fertility - genetics Genealogy Genetic diversity Genetic variance Genomes Haplotype Haplotypes Health Status Homozygosity Homozygote Humanities and Social Sciences Humans Inbreeding Inbreeding Depression Inbreeding Depression - genetics Life Sciences Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper multidisciplinary Offspring Phenotypes Reproduction Risk-Taking Santé publique et épidémiologie Science Science (multidisciplinary) Social factors Tumor necrosis factor-TNF
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Zusammenfassung:	In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients ( F ROH ) for >1.4 million individuals, we show that F ROH is significantly associated ( p
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-12283-6