Synthesis and Study of Building Blocks with Dibenzo[ b,f ]oxepine: Potential Microtubule Inhibitors

The synthesis of biphenylmethoxydibenzo[ ]oxepine or photoswitchable fluorinated dibenzo[ ]oxepine derivatives with one or three azo bonds, potential microtubule inhibitors, is described. Our studies provide a concise method for constructing derivatives containing the dibenzo[ ]oxepine skeleton. An analysis of products was run using experimental and theoretical methods. Next, we evaluated the / isomerization of -dibenzo[ ]oxepine derivatives, which could be photochemically controlled using visible-wavelength light.