Safety and effectiveness of remdesivir in hospitalized patients with COVID-19 and severe renal impairment: experience at a large medical center

Literature on the safety of remdesivir in hospitalized COVID-19 patients with severe renal impairment is limited. We aimed to investigate the safety and effectiveness of remdesivir in this population. We conducted a retrospective cohort study of adult hospitalized COVID-19 patients who received remd...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2024-12, Vol.56 (1), p.2361843-2361843
Hauptverfasser:	Chang, Hsuan-Yu, Hsu, Chia-Chen, Hu, Li-Fang, Chou, Chian-Ying, Chang, Yuh-Lih, Lu, Chih-Chia, Chang, Li-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - chemically induced Acute Kidney Injury - epidemiology Adenosine Monophosphate - adverse effects Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - therapeutic use Adult Aged Alanine - adverse effects Alanine - analogs & derivatives Alanine - therapeutic use Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Bradycardia - chemically induced Bradycardia - epidemiology COVID-19 COVID-19 - complications COVID-19 - mortality COVID-19 Drug Treatment Female Glomerular Filtration Rate Hospital Mortality Hospitalization - statistics & numerical data Humans Infectious Diseases Male Middle Aged remdesivir Renal Insufficiency - epidemiology Retrospective Studies SARS-CoV-2 severe renal impairment Treatment Outcome
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Zusammenfassung:	Literature on the safety of remdesivir in hospitalized COVID-19 patients with severe renal impairment is limited. We aimed to investigate the safety and effectiveness of remdesivir in this population. We conducted a retrospective cohort study of adult hospitalized COVID-19 patients who received remdesivir between April 2022 and October 2022. Outcomes were compared between estimated glomerular filtration rate (eGFR)
ISSN:	0785-3890 1365-2060
DOI:	10.1080/07853890.2024.2361843