Molecular analysis of cell‐free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

Molecular analysis of cell‐free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

Abbreviations SCLC: small cell lung cancer PFS: progression-free survival CNAs: copy number alterations APC : adenomatous polyposis coli TP53 : tumor protein 53 ATM : ataxiatelangiectasia mutated FLCN: folliculin PCA: principal component analysis SH2D5 : Src homology 2 domain containing protein 5 CA...

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Veröffentlicht in:Cancer Communications 2019-04, Vol.39 (1), p.1-5
Hauptverfasser: Zhang, Jie, Tian, Chen, Lv, Fang, Wang, Jianfei, Han, Wenbo, Nie, Jun, Dai, Ling, Hu, Weiheng, Chen, Xiaoling, Ma, Xiangjuan, Tian, Guangming, Wu, Di, Han, Sen, Wang, Yang, Long, Jieran, Zhang, Ziran, Fang, Jian, Zhang, Henghui
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Antineoplastic Agents - therapeutic use
Cell-Free Nucleic Acids - genetics
Colorectal cancer
Deoxyribonucleic acid
DNA
Drug Resistance, Neoplasm - genetics
Female
Genetic disorders
Humans
Kaplan-Meier Estimate
Letter to the Editor
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Male
Middle Aged
Mutation
Platinum Compounds - therapeutic use
Polyps
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - genetics
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Zusammenfassung:Abbreviations SCLC: small cell lung cancer PFS: progression-free survival CNAs: copy number alterations APC : adenomatous polyposis coli TP53 : tumor protein 53 ATM : ataxiatelangiectasia mutated FLCN: folliculin PCA: principal component analysis SH2D5 : Src homology 2 domain containing protein 5 CA12 : carbonic anhydrase 12 LMNA : lamin A/C PTCH1 : patched 1 LIG4 : DNA ligase 4 SNVs: single nucleotide variants
ISSN:2523-3548
2523-3548
DOI:10.1186/s40880-019-0363-y