Zearalenone induces apoptosis and autophagy by regulating endoplasmic reticulum stress signalling in porcine trophectoderm cells

Zearalenone induces apoptosis and autophagy by regulating endoplasmic reticulum stress signalling in porcine trophectoderm cells

Zearalenone (ZEA), a mycotoxin produced mainly by fungi belonging to Fusarium species in foods and feeds, causes a serious hazard to humans and animals. Numerous studies have revealed that ingesting ZEA can disrupt the reproductive function and impair the reproductive process in animals. This experi...

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Veröffentlicht in:Animal Nutrition 2023-03, Vol.12 (1), p.186-199
Hauptverfasser: Bai, Jun, Li, Jun, Liu, Ning, Jia, Hai, Si, Xuemeng, Zhou, Yusong, Zhai, Zhian, Yang, Ying, Ren, Fazheng, Wu, Zhenlong
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Autophagy
Endoplasmic reticulum stress
Porcine trophectoderm
Zearalenone
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Zusammenfassung:Zearalenone (ZEA), a mycotoxin produced mainly by fungi belonging to Fusarium species in foods and feeds, causes a serious hazard to humans and animals. Numerous studies have revealed that ingesting ZEA can disrupt the reproductive function and impair the reproductive process in animals. This experiment was to investigate the toxicological effect and the mechanism of ZEA exposure on reproduction in pigs during early stages of pregnancy. In the present study, we treated with 0 to 80 μmol/L ZEA for 12 or 24 h in trophoblast ectoderm (pTr) cells. The results showed that ZEA had significantly decreased cell proliferation (P 
ISSN:2405-6545
2405-6383
DOI:10.1016/j.aninu.2022.08.016