Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

•RUNX1a, but not RUNX1b, is overexpressed in CD34+ cells from patients with myelodysplastic/myeloproliferative neoplasms.•SRSF2P95H mutation induces RUNX1a overexpression and a monocytic phenotype in TF-1 cells.

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Veröffentlicht in:Blood advances 2017-08, Vol.1 (18), p.1382-1386
Hauptverfasser: Sakurai, Hiroko, Harada, Yuka, Ogata, Yosuke, Kagiyama, Yuki, Shingai, Naoki, Doki, Noriko, Ohashi, Kazuteru, Kitamura, Toshio, Komatsu, Norio, Harada, Hironori
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Sprache:eng
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Stimulus Report
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Zusammenfassung:•RUNX1a, but not RUNX1b, is overexpressed in CD34+ cells from patients with myelodysplastic/myeloproliferative neoplasms.•SRSF2P95H mutation induces RUNX1a overexpression and a monocytic phenotype in TF-1 cells.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2016002725