Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by which could colonize within the gastric mucosa of the infected cases. To date, triple antibiotic therapy has routinely been utilized for controlling the induced infection. However, this strategy has been unsuccessful, in large part because of issues such as occurring point mutations in the genome that can induce resistance to the antibiotics administered. Recently, it has been shown that different probiotics may have strong anti-cancer effects, in which they are capable of inhibiting by both immunological and non-immunological mechanisms. Here, we aimed at finding possible anti-cancer impacts of the probiotic bacterium on gastric cancer, AGS cells. The anti-cancer effects of the conditioned media of the locally isolated on the AGS cells were evaluated by different analyses such as flow cytometry, DNA ladder assay, DAPI staining, and RT-PCR. Our findings showed that the conditioned media of can inhibit both and AGS cells through up-/down-regulation of PTEN, Bax, TLR4, and AKT genes. The exudates of the probiotic bacteria can increase the expression of PTEN, Bax, and TLR4, and also decrease the expression of AKT gene. In agreement with different reports, our results proved the anti-cancer effects of the locally isolated through some immunological cell signaling pathways. Accordingly, it seems the probiotics could be considered as at least a complementary treatment for different types of malignancies.