Antioxidant effects of magnesium in reducing oxidative stress by injected via an intraperitoneally carbon tetrachloride in the Wistar male adult rats

introdaction & aim: Magnesium playes an important role in the structure and cell metabolism. In this research , anti oxidant effects of magnesium sulfate against oxidative stress effects of was investigated Methods: In this experimewtal study 36 male adults rats were placed into4 groups, with nine rats in each group. Treatment was then carried out as follows. Group I received olive oil (intraperitoneally) and distilled water (intragastrically), and served as the untreated control animal group. Group II was the hepatotoxicity group that was given a suspension of (i.p., 0.5 mL/kg b.wt, 50% in olive oil), twice a week. Groups III received dissolved in distilled water daily via an intragastric tube(.0.15M g/kg b.wt.)Groups IV were the treatment group that received dissolved in distilled water daily, via an intragastric tube 0.15 g/kg b.wt.),with (i.p., 0.5 mL/kg b.wt., 50% in olive oil) twice a week. After a 28-day treatment period, the animals were deprived of food overnight, anesthetized by exposure to diethyl ether, and then sacrificed by decapitation. Blood ws collected from the jugular vein, and serum was separated and used for liver marker assays. Levels of ALT, AST ALP and GGT were estimated using commercial kits. The liver homogenates were used for the assay of SOD .All data were expressed as means S.E.M. Statistical analysis was carried out using one-way ANOVA followed by a Tukey post hoc test. The criterion for statistical significance was p