Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance?

It has been given current information about acute and late adverse reactions arising from the use of gadolinium magnetic resonance contrast agents (GMRCA). The role of thermodynamic and kinetic stability GMRCA in the deposition of gadolinium in tissues, including the brain, the development of pseudohypoglycemia and nephrogenic systemic fibrosis (NSF) is considerated. After analysis of data on mechanisms of deposition of gadolinium in the body's cells and mechanisms of cytotoxicity on the chemical structure of existing GMRCA it is concluded that for reducing the accumulation of gadolinium in cells and the risk of development of NSF is advisable to use stable macrocyclic agents such as gadobutrol.