Increased extravascular lung water index (EVLWI) reflects rapid non-cardiogenic oedema and mortality in COVID-19 associated ARDS

Nearly 5% of patients suffering from COVID-19 develop acute respiratory distress syndrome (ARDS). Extravascular lung water index (EVLWI) is a marker of pulmonary oedema which is associated with mortality in ARDS. In this study, we evaluate whether EVLWI is higher in patients with COVID-19 associated...

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Veröffentlicht in:Scientific reports 2021-06, Vol.11 (1), p.11524-11524, Article 11524
Hauptverfasser: Rasch, Sebastian, Schmidle, Paul, Sancak, Sengül, Herner, Alexander, Huberle, Christina, Schulz, Dominik, Mayr, Ulrich, Schneider, Jochen, Spinner, Christoph D., Geisler, Fabian, Schmid, Roland M., Lahmer, Tobias, Huber, Wolfgang
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Sprache:eng
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Zusammenfassung:Nearly 5% of patients suffering from COVID-19 develop acute respiratory distress syndrome (ARDS). Extravascular lung water index (EVLWI) is a marker of pulmonary oedema which is associated with mortality in ARDS. In this study, we evaluate whether EVLWI is higher in patients with COVID-19 associated ARDS as compared to COVID-19 negative, ventilated patients with ARDS and whether EVLWI has the potential to monitor disease progression. EVLWI and cardiac function were monitored by transpulmonary thermodilution in 25 patients with COVID-19 ARDS subsequent to intubation and compared to a control group of 49 non-COVID-19 ARDS patients. At intubation, EVLWI was noticeably elevated and significantly higher in COVID-19 patients than in the control group (17 (11–38) vs. 11 (6–26) mL/kg; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91043-3