Intravenous Nanocarrier for Improved Efficacy of Quercetin and Curcumin against Breast Cancer Cells: Development and Comparison of Single and Dual Drug-Loaded Formulations Using Hemolysis, Cytotoxicity and Cellular Uptake Studies

Intravenous Nanocarrier for Improved Efficacy of Quercetin and Curcumin against Breast Cancer Cells: Development and Comparison of Single and Dual Drug-Loaded Formulations Using Hemolysis, Cytotoxicity and Cellular Uptake Studies

The present work highlights the suitability of an oil-based nanocarrier to deliver quercetin (Q) and curcumin (C) through the intravenous route for treatment of breast cancer. The nanoemulsion prepared by the modified emulsification-solvent evaporation method resulted in particle size (

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Bibliographische Detailangaben
Veröffentlicht in:Membranes (Basel) 2022-07, Vol.12 (7), p.713
Hauptverfasser: Rahman, Mohammad Akhlaquer, Mittal, Vineet, Wahab, Shadma, Alsayari, Abdulrhman, Bin Muhsinah, Abdullatif, Almaghaslah, Dalia
Format: Artikel
Sprache:eng
Schlagworte:
Bioavailability
Biocompatibility
Blood
Breast cancer
Cancer therapies
cellular uptake
Controlled release
Curcumin
Cytotoxicity
Drug delivery
Drug delivery systems
Drugs
Efficiency
Emulsification
Emulsions
Evaporation
hemocompatibility
Hemodialysis
Hemolysis
Internalization
Intravenous administration
Nanoemulsions
Nanotechnology
Osmolarity
Pharmacokinetics
Polydispersity
Quercetin
Sustained release
Synergistic effect
Toxicity
Viscosity
Zeta potential
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Beschreibung
Zusammenfassung:The present work highlights the suitability of an oil-based nanocarrier to deliver quercetin (Q) and curcumin (C) through the intravenous route for treatment of breast cancer. The nanoemulsion prepared by the modified emulsification-solvent evaporation method resulted in particle size (
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes12070713