The epitome of tailor-made short positively charged peptides against HCC via integrated pharmacology

The SPCPs can destroy the CCM with negatively charged residues, which is optimal to develop suitable agents. [...]SPCPs obtained by R Package filtered to select significant SPCPs with stable physicochemical properties via the reliable web-based bioinformatics tools. [...]the targets on SPCPs were retrieved by Similarity Ensemble Approach (376 targets) and SwissTargetPrediction (380 targets), indicating that the overlapping targets (244 targets) might be significant elements in SPCPs (Additional file 2: [...]in the molecular docking test, the two SPCPs (KFAH, and HFAK) formed the most stable complex on the 5 key targets (Fig. 1I).