RNA m6A modification orchestrates the rhythm of immune cell development from hematopoietic stem cells to T and B cells
RNA, one of the major building blocks of the cell, participates in many essential life processes. RNA stability is well-established to be closely related to various RNA modifications. To date, hundreds of different RNA modifications have been identified. N6-methyladenosine (m 6 A) is one of the most...
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Veröffentlicht in: | Frontiers in immunology 2022-07, Vol.13, p.839291-839291 |
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Sprache: | eng |
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Zusammenfassung: | RNA, one of the major building blocks of the cell, participates in many essential life processes. RNA stability is well-established to be closely related to various RNA modifications. To date, hundreds of different RNA modifications have been identified. N6-methyladenosine (m
6
A) is one of the most important RNA modifications in mammalian cells. An increasing body of evidence from recently published studies suggests that m
6
A modification is a novel immune system regulator of the generation and differentiation of hematopoietic stem cells (HSCs) and immune cells. In this review, we introduce the process and relevant regulatory mechanisms of m
6
A modification; summarize recent findings of m
6
A in controlling HSC generation and self-renewal, and the development and differentiation of T and B lymphocytes from HSCs; and discuss the potential mechanisms involved. |
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ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2022.839291 |