Phytochemical Study of Stem and Leaf of Clausena lansium

Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus , including a new aromatic glycoside ( ), a new dihydrofuranocoumarin glycoside ( ), and two new sesquiterpene glycosides ( and ). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of in the genus and suggests that some glycosides from this plant probably play a role in the anticancer activity of to some extent.